George Henry Alexander Clowes was a pivotal figure in the development of the insulin program at the Eli Lilly Company. Through his leadership, scientists and clinicians at Lilly and the University of Toronto created a unique, international team to develop and purify insulin and take the production of this life-saving agent to an industrial scale. This biography, written by his grandson, presents his scientific achievements, and also takes note of his social and philanthropic contributions, which he shared with his wife, Edith. It tells the story of Clowes from his childhood in late Victorian England to his death at Woods Hole on Cape Cod in 1958. Educated in England and Germany, Clowes came to America to join a startup laboratory in Buffalo, where he conducted basic research on cancer and applied research on other disease-related problems. Assuming the position of head of research at Lilly, Clowes was at the center of one of the great discoveries that changed the course of medical history and offered new life to millions of individuals with diabetes and other metabolic disorders. Clowes was also instrumental in the development of other commercial pharmaceutical advances. Devoted to a number of philanthropic causes, Clowes and Edith contributed greatly to the cultural life of his adopted country, a contribution that continues to this day.
|The Doc and the Duchess is a must-read for anyone interested in drug development, medical history, and diabetes. Clowes gives us a thorough, compelling, and important book, offering unprecedented insight into his grandfather, whose extraordinary gift for inspiring scientists to work together long predated modern concepts of networking and teambuilding. The letters, interviews, and family lore illuminate an original thinker with a personality as irresistible on the page as it must have been in person.This well-researched book celebrates the lives of George H. A. and Edith Clowes. GHA Clowes’ advanced research made Eli Lilly and Company a world leader in the development of insulin and played a critical role in Lilly's development into a global pharmaceutical company.Vividly told, the book captures the personalities of the protagonists, contains scientifically sophisticated explanations about the development of marketable insulin, and invokes the evolving environment—economic, medical, social, and familial—in which the story takes place.This is a fascinating story about an incredible man, his wife, and his family. Everyone interested in the early days after the discovery of insulin will want to read this book.A delight to read--well written and authoritative. This is an insider's story, lovingly told.
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Table of Contents
Foreword / John Lechleiter
Introduction: A Warm Embrace
1. Growing Up in Victorian England
2. The Search for a Cure of Cancer
3. Edith Whitehill Hinkel
4. Alec and Edith
5. 1914: The End of an Era
6. In the Borderline Fields of Medicine
7. Lilly and the Insulin Story
8. From Small to Large Scale Production of Insulin
9. Expansion of the Research Programs
10. Woods Hole, MBL, and the Pursuit of Cancer
11. The Duchess, The Doc and The Boys
12. Alec and Edith: Indianapolis Benefactors
13. A Legacy: In Others’ Eyes
Appendix I: Publications of George Henry Alexander Clowes
Appendix II: Chronology of Ancestry